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Resources:
OCT in MS Care

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Infographic

Our easy-to-follow infographic breaks down the essential steps for leveraging OCT imaging to support multiple sclerosis diagnosis and monitoring.

Whitepaper

Explore our whitepaper describing JuneBrain's innovative Neuro-i SS-OCT system and how retinal imaging enhances the diagnosis and management of neurodegenerative conditions for better patient outcomes

Publications

Explore the growing body of research highlighting the power of OCT data in advancing our understanding and treatment of neurodegenerative conditions like MS.

References:

1. Saidha, Shiv, et al. "Relationships between retinal axonal and neuronal measures and global central nervous system pathology in multiple sclerosis." *JAMA neurology* 70.1 (2013): 34-43.

2. Saidha, Shiv, et al. "Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography." *Brain* 134.2 (2011): 518-533.

3. Saidha, Shiv, et al. "Optical coherence tomography reflects brain atrophy in multiple sclerosis: a four‐year study." *Annals of neurology* 78.5 (2015): 801-813.

4. Syc, Stephanie B., et al. "Optical coherence tomography segmentation reveals ganglion cell layer pathology after optic neuritis." *Brain* 135.2 (2012): 521-533.

5. Maccora, Katia A., Shivanand Sheth, and Jonathan B. Ruddle. “Optical coherence tomography in paediatric clinical practice.” *Clinical and Experimental Optometry* 102.3 (2019): 300-308.

6. Al-Louzi, Omar, et al. “Characteristics of morphologic macular abnormalities in neuroimmunology practice.” *Multiple Sclerosis Journal* 25.3 (2019): 361-371.

7. Nolan‐Kenney, Rachel C., et al. “Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: an international study.” *Annals of neurology* 85.5 (2019): 618-629.

8. Sotirchos, Elias S., et al. “Progressive multiple sclerosis is associated with faster and specific retinal layer atrophy.” *Annals of neurology* 87.6 (2020): 885-896.

9. Cadavid, Diego, et al. “Safety and efficacy of opicinumab in acute optic neuritis (RENEW): a randomised, placebo-controlled, phase 2 trial.” *The Lancet Neurology* 16.3 (2017): 189-199.

10. Peng, Anjiao, et al. “Evaluation of the retinal nerve fiber layer in neuromyelitis optica spectrum disorders: a systematic review and meta-analysis.” *Journal of the neurological sciences* 383 (2017): 108-113.

11. Gelfand, Jeffrey M., et al. “Microcystic macular oedema in multiple sclerosis is associated with disease severity.” *Brain* 135.6 (2012): 1786-1793.

12. Kaufhold, Falko, et al. “Optic neuritis is associated with inner nuclear layer thickening and microcystic macular edema independently of multiple sclerosis.” *PloS one* 8.8 (2013): e71145.

13. Henderson, Andrew PD, et al. “A serial study of retinal changes following optic neuritis with sample size estimates for acute neuroprotection trials.” *Brain* 133.9 (2010): 2592-2602.

14. Naismith, R., et al. Radial diffusivity in remote optic neuritis discriminates visual outcomes. *Neurology*, 2010. 74(21): p. 1702-1710.

15. Brar, Manpreet, et al. “Correlation between morphological features on spectral domain optical coherence tomography and angiographic leakage patterns in macular edema.” *Retina (Philadelphia, Pa.)* 30.3 (2010): 383.

16. Fisher, J.B., et al. Relation of visual function to retinal nerve fiber layer thickness in multiple sclerosis. *Ophthalmology*, 2006, 113(2): p. 324-332.

17. Costello, F., et al. Quantifying axonal loss after optic neuritis with optical coherence tomography. *Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society*, 2006. 59(6): p. 963-969.

18. Shindler, K.S., et al. Inflammatory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritis. *Experimental eye research*, 2008. 87(3): p. 208-213.

19. Kelty, Patrick J., et al. “Macular thickness assessment in healthy eyes based on ethnicity using Stratus OCT optical coherence tomography.” *Investigative ophthalmology & visual science* 49.6 (2008): 2668-2672.

20. Warner, C.V., et al. The impact of utilizing different optical coherence tomography devices for clinical purposes and in multiple sclerosis trials. *PLoS One*, 2011. 6(8): p. e22947.

21. Levin, Marc H., Jeffrey L. Bennett, and A. S. Verkman. “Optic neuritis in neuromyelitis optica.” *Progress in retinal and eye research* 36 (2013): 159-171.

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